Private eyes of mine

EDUCATIONAL

A miniworld on a picture

Just the other day, while surfing around the internet I came across this website http://gigapixel-dresden.de/dresden26GP .  As the website mentions it is the interactive snapshot of the town of Dresden, Germany.

 

 

“It consists of 1.665 full format pictures with 21.4 megapixel, which was recorded by a photo-robot in 172 minutes. The converting of 102 GB raw data by a computer with a main memory cache of 48 GB and 16 processors took 94 hours. With a resolution of 297.500 x 87.500 pixel (26 gigapixel) the picture is the largest in the world. (stand December 2009)”

Just caught my imagination. For others check http://www.afb-media.de/


Primary esophageal lymphoma in immunocompetent patients: Two case reports and literature review

 

 
World J Radiol. 2010 August 28; 2(8): 334-338.
Published online 2010 August 28. doi: 10.4329/wjr.v2.i8.334.
 
Copyright©2010 Baishideng Publishing Group Co., Limited. All rights reserved.
 
Primary esophageal lymphoma in immunocompetent patients: Two case reports and literature review
Prasanna Ghimire, Guang-Yao Wu and Ling Zhu.
  
Prasanna Ghimire, Guang-Yao Wu, Ling Zhu, Department of Magnetic Resonance Imaging, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, China
Author contributions: Ghimire P served as the primary author, reviewed the literature and wrote the case report; Wu GY and Ling Z reviewed the manuscript.
Correspondence to: Guang-Yao Wu, MD, PhD, Department of Magnetic Resonance Imaging, Zhongnan Hospital, Wuhan University, 169 East Lake Road, Wuhan 430071, Hubei Province, China. wuguangy2002@yahoo.com.cn
Telephone: +86-27-67813187 Fax: +86-27-67813188
Received May 4, 2010; Revised May 27, 2010; Accepted June 4, 2010;
 
Abstract
Primary lymphoma that involves the esophagus is very rare, with fewer than 30 cases reported in the English-language literature. Non-Hodgkin lymphoma accounts for most of the cases. Esophageal lymphomas have varied radiological appearances, which poses diagnostic difficulty. We report two cases of histopathologically confirmed primary diffuse large B-cell esophageal lymphoma and describe their radiological features, and briefly review the literature.
Keywords: Esophageal neoplasms, Non-Hodgkin lymphoma, Primary lymphoma, Esophagography, Computed tomography
 

HEALTH SECTOR IN NEPAL AND ITS CHALLENGES

 As in many developing nations, health care in Nepal is provided jointly by the government and the private sector. The private sector is mostly profit oriented and is barely providing health care to the privileged group. The public health institutions are however the only hope for the remaining larger population. The services at these institutions are either not within reach of the majority of the population or simply lack the adequate man power, technology and infrastructure to provide the care for the needy.

According to the World Health Organization report on 2000 of the assessment of the world’s health systems, Nepal ranked 150th out of the 191 member states. The report also highlighted the important fact that Nepal was one the countries which was having the least fair financing of the health system. This had been attributed to the inequitable distribution of the health care to the general population with failure in the implementation of the running health programmes.

The Alma-Ata declaration of 1978 to which Nepal abided to, affirmed health as a fundamental human right and that the highest possible level of health is a most important world-wide social goal whose realization requires the action of many other social and economic sectors in addition to the health sector. Nepal has been adopting the primary health care (PHC) with essential PHC services for the last two decades. Various goals and targets were set for ‘Achieving Health For All by the Year 2000’; some of the goals include at least 5% of gross national product should be spent on health; at least 90% of children should have a weight for age that corresponds to the reference values; safe water should be available in the home or within 15 minutes’ walking distance, and adequate sanitary facilities should be available in the home or immediate vicinity; people should have access to trained personnel for attending pregnancy and childbirth; and child care should be available up to at least one year of age.

Nepal had developed and adopted a national health policy in 1991. A 20 year (1997- 2017) Second Long Term Health Plan (SLTHP) is also being implemented which mainly aims at improving the health status of the underprivileged, the most vulnerable groups, women and children, the rural population, and the marginalized. This was promulgated to deliver essential health care in equitable distribution to the community with their full participation by means of technically competent and socially responsible health personnel. Different national health programmes were devised to curtail the existing health problems; however these programmes achieved relatively few successes when considering benefit to the aimed population.  The reason for failure of these national health programmes can be attributed to be multifactorial. The most noteworthy factors that can be attributed to this are the lackadaisical approach by government officials and bureaucrats, non-scientific allocation of resources and uncoordinated implementation. The health ministry bewildered by its internal as well as external chaos also fails to enforce regulations that they themselves have created or are supposed to implement in the public interest. The availability of the resources at time s has not been justifiably utilized with waste of the medicines or facilities as expired or unusable state. By proper channels and coordination of the various levels of this chain of health system, this could be avoided and thus those facilities be utilized by the needy people. The Jajarkot incidence which took a heavy toll of life by a mere diarrhea or an outbreak of measles can exemplify how efficient and expedite management is of the government and health system to tackle any disasters. As a further setback, the existing allocations for the health sector have been curtailed off in the name for the various general development programmes which would barely exist.

A note must also be made to the volatile political scenario of the country which poses a great impact to the health sector. The monopoly and biased appointments have created havoc as seen in the recent shutdown of major hospitals with the brunt of the impact going to the marginalized society who cannot afford the expense of aristocratic private hospitals. Lack of security at working place, no proper incentive to the workers has led to massive brain drain in the medical field thus adding to the ongoing health related crisis. It should however be commented that the disarray in health sector doesn’t lie on the government alone but a major role also does play from the community as well as the medical fraternity itself. The various bandhs and inhumanly attitude of a part of the community has further dragged the health sector to dismay. The implementation of various essential health services and provision of emergency services to the needy have been affected immensely resulting in increase of the already high morbidities and mortalities.

The integrity of the medical fraternity itself is also in a mess and can also be questioned. In recent times, an inharmonious difference among the fraternity has also been an inculcating process to the disgrace of the medical community in general. Politicization and segmentalization of the institution has been a root for the dividend of the medical professionals. Be it the medical council’s election or any appointment of the members of the medical association, we have witnessed how much the system have been supervened by these processes. This has led to the deterioration of the already crippled health system thus warranting a drastic change to revert it. Over impulsive propagation of the hierarchy has also led to mistrust and bitter relations among the medical workers. Besides, the various incidences depict the widespread corruption, bribery, moonlighting and other illegal practices being practiced and encouraged by the health professionals themselves. The evil of commission, nepotisms has rooted so deeply that it deems very much imperative to wipe it from the bottom lest it corrodes the entire society.

 Recently it has been advocated that health insurance system be implemented to the large population. In a country where approximately 30 % of the population is living under the poverty line, although virtually it may appear beneficial to the poorest people, it however doesn’t seem quite practicable and realistic at the present context of the economic instability of the country. A more rational approach would be the proper training of the health workers, proper implementation and distribution of the available resources and education of the community from the grass-root level, to achieve the expected goals.

A sound vision from the policy makers with proper implementation of the programmes, an attitude of humanity above self from the medical professionals and a thorough commitment from the community will definitely be a boon to the health care system thus making a healthier Nepal.


BRANCHES OF ABDOMINAL AORTA

 BRANCHES OF ABDOMINAL AORTA

Branch

Vertebra Type Paired A/P

Description

inferior phrenic T12 Parietal yes P originates just below the diaphragm, supplying it from below
celiac T12 Visceral no A
  1. left gastric a.
  2. splenic a.
    1. short gastric arteries (6)
    2. splenic arteries (6)
    3. left gastroepiploic a.
  3. hepatic a.
    1. cystic a.
    2. right gastric a.
    3. gastroduodenal a.
      1. right gastroepiploic a.
      2. superior pancreaticoduodenal a.
  4. right hepatic a.
  5. left hepatic a.
superior mesenteric L1 Visceral no A
  1. jejunal and ileal arteries
  2. inferior pancreaticoduodenal a.
  3. middle colic a.
  4. right colic a.
  5. ileocolic a.
    1. anterior cecal a.
    2. posterior cecal a. – appendicular a.
    3. ileal a.
    4. colic a.
middle suprarenal L1 Visceral yes P to adrenal gland
renal L1 Visceral yes P large artery, each arising from the side of the aorta; supplies corresponding kidney; arises in the transpyloric plane
gonadal L2 Visceral yes P ovarian artery in females; testicular artery in males
lumbar L1-L4 Parietal yes P four on each side that supply the abdominal wall and spinal cord
inferior mesenteric L3 Visceral no A
  1. left colic a.
  2. sigmoid arteries (2 or 3)
  3. superior rectal a.
median sacral L4 Parietal no P  
common iliac L4 Terminal yes P
  1. external iliac a.
  2. internal iliac a.

 Source: wikipedia


RESPIRATORY PNEUMONICS

RESPIRATORY PNEUMONICS

Interstitial Lung Disease

Sarcoid
Histiocytosis X
Idiopathic Pulmonary Fibrosis
Tumor (Lymphangitic)
Failure
Asbestosis (and other dusts)
Collagen Vascular Disease
Environmental dusts (organic – farmer’s lung, inorganic – silica, coal)
Drug

ABC’s of Trauma
The chest radiograph is an economical and sensitive screening examination for the major injuries in the patient who has sustained blunt chest trauma. Just as the physician uses the ABC’s to stabilize the critical ill patient (Airway, Breathing, Circulation), the radiologic ABC’s prompt the radiologist to consider all of the critical injuries that may be sustained with blunt trauma. THE most critical injury is considered first.

Aortic Transection
Bronchial fracture
Cord injury (Thoracic spine)
Diaphragmatic rupture
Esophageal tear
Flail chest
Gas (subtle pneumothorax)
Heart (Cardiac injury)
Iatrogenic (Misplaced monitoring & support catheters)
 
PEARL: Causes of Unilateral Lung Disease 
 

Pneumonia
Edema
Aspiration
Radiation
Lymphangtic Tumor
 
 
FAT PAD: Cardiophrenic angle mass 
Fat
Pericardial cyst
Adenopathy/Aneurysm
Diaphragmatic Hernia
 
BIG HIPS: Honeycomb Lung
             Bleomycin
Idiopathic
Granulomas
Histiocytosis X
Interstitial pneumonia
Pneumoconiosis
Sarcoid
 
Late Night Sex: Interstitial lung disease & Hyperinflation 
 

Lymphangiomyomatosis
Neurofibromatosis
Sarcoid
Emphysema
X, histiocytosis

Balls: Nodules with Air Bronchograms 

BAC
Amyloid
Lymphoma
Lipoid pneumonia
Sarcoid

Balls: Chronic Airspace Disease
              Bronchoalveolar carcinoma
BOOP
Aspiration
Alveolar proteinosis
Lipoid pneumonia
Loeffler’s (chronic eosinophilic pneumonia)
Lymphoma
Pseudolymphoma
Sarcoid (alveolar)

Set Carp: Apical Lung Disease 

Sarcoid
EG, Eosinophilic pneumonia
Tuberculosis
Cystic Fibrosis
Ankylosing spondylitis
Radiation therapy
PCP (cystic)
Pneumoconiosis

Bad Rash: Basilar Lung Disease

Bronchiectasis, BOOP
Aspiration
Drugs
Rheumatoid
Asbestosis
Scleroderma
Hamman-Rich

YES CT: Germ Cell Tumors  

Yolk Sac Tumors
Embryonal cell carcinoma
Seminoma
Choriocarcinoma
Teratoma

Systemic Pulmonary Artery Shunts 

Good Glenn ( SVC to RPA )
Flow Fontan ( RA to RV )
Really Rastelli ( RV to RPA )
Would Waterston-Cooley ( RPA to AA )
Be Blalock-Taussig ( RPA to subclavian )
Perfect Potts ( LPA to DA )

Contrast Enhancing Mediastinal Mass

Capt/Capt
Castleman
Aneurysm
Paraganglioma
Thryoid
Carcinoid
Aneurysm (so important needs to be mentioned twice)
Parathyroid
Tuberculosis
O Captian! My Captian
O Captain! my Captian! our fearful trip is done;
The ship has weather’d every rack, the prize we sought is won;
The port is near; the bells I hear; the people all exulting,
While follow eyes the steady keel, the vessel grim and daring, Walt Whitman

Multiple thin-walled cavities

Pitch
Pneumatocele + bullae
Infections (Tb, cocci)
Tumors (Squamous cell)
Cysts (bronchogenic, trauma)
Hydrocarbon ingestion

Solitary Lung Mass

CASH PLEASE (if you miss it!)
Cancer
Abscess
Solitary met
Hamartoma
Psuedotumor
Lymphoma
Echinococcus
Actinomycosis
Sequestration

Calcifying Metastases

BOTTOM
Breast
Osteogenic carcinoma
Thyroid (papillary)
Ovarian
Mucinous adenocarcinoma

Multiple Pleural Masses

MALLETS
Mesothelioma
Adenocarcinoma
Lymphoma
Leukemia
Empyema
Thymoma
Splenosis

Cavity

Cancer
Autoimmune (Wegeners, RA)
Vascular (septic emboli)
Infectious (Tb, Abscess)
Trauma
Young (bronchogenic cyst, laryngotracheal papillomatosis)

 

Reference: http://www.chestx-ray.com/Education/Educat.html


PANCREATITIS: BALTHAZAR SEVERITY INDEX

Pancreatitis: BALTHAZAR SEVERITY INDEX

Balthazar severity index:
CT appearance:
Normal – 0 points
Large pancreas – 1 point
Pancreatic/ peripancreatic inflammation – 2
1 fluid collection – 3
2 fluid collection – 4
% necrosis:
0 – 0
<> 50% – 6
Score of 0 – no mortality, score 7 to 10 – 17% mortality

HEPATITIS B

Serological markers of HBV infection 

During HBV infection, the serological markers vary depending on whether the infection is acute or chronic.11, 23, 31

Antigens Antibodies
 HBsAg Hepatitis B surface antigen is the earliest indicator of acute infection and is also indicative of chronic infection if its presence persists for more than 6 months. It is useful for the diagnosis of HBV infection and for screening of blood. 

Its specific antibody is anti-HBs. 

 anti-HBsThis is the specific antibody to hepatitis B surface antigen. Its appearance 1 to 4  monthsafter onset of symptoms indicates clinical recovery and subsequent immunity to HBV.Anti-HBs can neutralize HBV and provide protection against HBV infection. 
 HBcAgHepatitis B core antigen is derived from theprotein envelope that encloses the viral DNA, and it is not detectable in the bloodstream. When HBcAg peptides are expressed on the surface of hepatocytes, they induce an immune response that is crucial for killing infected cells. The HBcAg is a marker of the infectious viral material and it is the most accurate index of viral replication. Its specific antibody is anti-HBc.   anti-HBcThis is the specific antibody to hepatitis B coreantigen. Antibodies to HBc are of class IgM andIgG. They do not neutralize the virus. The presence of IgM identifies an early acute infection. In the absence of HBsAg and anti-HBs, it shows recent infection. IgG with no IgM may be present in chronic and resolved infections.Anti-HBc testing identifies all previously infected persons, including HBV carriers, but does not differentiate carriers and non-carriers. 
 HBeAgHepatitis B e antigen appearing during weeks 3 to 6 indicates an acute active infection at its most infectious period, and means that the patient is infectious. Persistence of this virological marker beyond 10 weeks shows progression to chronic infection and infectiousness. Continuous presence ofanti-HBe indicates chronic or chronic active liver disease. HBeAg is not incorporated into virions, but is instead secreted into the serum. Mutant strains of HBV exist that replicate without producing HBeAg. HBeAg’s function is uncertain. 

Its specific antibody is anti-HBe. 

 antiHBeThis is the specific antibody to hepatitis B eantigen. During the acute stage of infection theseroconversion from e antigen to e antibody is prognostic for resolution of infection. Its presence in the patient’s blood along withanti-HBc and in the absence of HBsAg, anti-HBsand core HBV mutants indicates low contagiousness and convalescence. 31 
 HBxAg Hepatitis B x antigen is detected in HBeAg positive blood in patients with both acute and chronic hepatitis. HBxAg is a transcriptional activator. It does not bind to DNA. Its specific antibody is anti-HBx.               anti-HBx This is the specific antibody to hepatitis B xantigen. It appears when other virological markers are becoming undetectable. 
 HBV DNA HBV DNA is detectable by hybridization assays or PCR as soon as 1 week after initial infection. The tests are generally performed for monitoring of antiviral treatment or to detect mutants that escape detection by current methods.   
 HBV DNA polymerase Tests for the presence of HBV DNA polymerase, detectable within 1 week of initial infection, are only performed for research purposes.   

 HBV serological markers in hepatitis patients 

The three standard blood tests for hepatitis B can determine if a person is currently infected with HBV, has recovered, is a chronic carrier, or is susceptible to HBV infection.15, 23, 31

Assay results  Interpretation
HBsAg  anti-HBs anti-HBc
 +  –  –  Early acute HBV infection
 +  +/-  +  Acute or chronic HBV infection. Differentiate with IgM-anti-HBcDetermine level of infectivity with HBeAg or HBV DNA.  
 –  +  +  Indicates previous HBV infection and immunity to hepatitis B.
 –  –  +  Possibilities include: past HBV infection; low-level HBVcarrier; time span between disappearance of HBsAg and appearance of anti-HBs; or false-positive or nonspecific reaction. Investigate with IgM anti-HBc, and/or challenge with HBsAg vaccine. When present,anti-HBe helps validate the anti-HBc reactivity.
 –  –  –  Another infectious agent, toxic injury to the liver, disorder of immunity, hereditary disease of the liver, or disease of the biliary tract.
 –  +  – Vaccine-type response.

 From: Hollinger FB, Liang TJ. Hepatitis B Virus. In: Knipe DM et al., eds. Fields Virology, 4th ed., Philadelphia, Lippincott Williams &Wilkins, 2001:2971-3036,15 with permission (http://lww.com). 

Interpretation of HBV serologic markers in patients with hepatitis.15 


Serological test findings at different stages of HBV infection and in convalescence

      anti-HBc    
Stage of infection HBsAg anti-HBs IgG IgM HBeAg anti-HBe
 late incubation period  +  –  –    + or –  –
 acute hepatitis B or persistent carrier state  +  –  +  +  +  –
 HBsAg-negative acute hepatitis B infection  –  –  –  +  –  –
recovery with loss of detectable anti-HBs  –  –  +  –  –  –
 healthy HBsAg carrier    +  –  +++  + or –  –  +
 chronic hepatitis B, persistent carrier state  +  –  +++  + or –  +  –
 HBV infection in recent past, convalescence  –  ++  ++  + or –  –  +
 HBV infection in distant past, recovery  –  + or –  + or –  –  –  –
 recent HBV vaccination, repeated exposure toantigen without infection, or recovery from infection with loss of detectable anti-HBc  –  ++  –  –  –  –

 From: Robinson WS. Hepatitis B virus and hepatitis D virus. In: Mandell GL, Bennett JE, Dolin R, eds.Principles and Practice of Infectious Diseases, 4th ed. New York, Churchill Livingstone, 1995:1406-1439,31 with permission. 

Hepatitis B virus serological markers in different stages of infection and convalescence.23, 31, 52 


Discordant or unusual hepatitis B serological profiles requiring further evaluation 

Repeat testing of the same sample or possibly of an additional sample is advisable when tests yield discordant or unusual results.15

 HBsAg positive / anti-HBc negative  An HBsAg-positive response is accompanied by an anti-HBc negative reaction only during the incubation period of acute hepatitis B, before the onset of clinical symptoms and liver abnormalities.
 HBsAg positive / anti-HBs positive / 
anti-HBc positive
 Uncommon, may occur during resolution of acute hepatitis B, in chronic carriers who have serious liver disease, or incarriers exposed to heterologous subtypes of HBsAg.
 anti-HBc positive only  Past infection not resolved completely
 HBeAg positive / HBsAg negative  Unusual
 HBeAg positive /  anti-HBe positive  Unusual
 anti-HBs positive only in anonimmunized person    It may be a result of passive transfer of anti-HBs after transfusion of blood from a vaccinated donor, in patients receiving clotting factors, after IG administration, or in newborn children of mothers with recent or past HBV infection.Passively acquired antibodies disappear gradually over 3 to 6 months, whereas actively produced antibodies are stable over many years. Apparently quite common when person has forgotten his/her immunization status! 

 Mutant proteins from mutant HBV strains may escape diagnostic detection. The presence of different serological markers should therefore be tested for a correct diagnosis. Diagnostic kits should containantibodies against a variety of mutant proteins, if perfection is the goal. 


Prevalence of hepatitis B in various areas

  % of population positive for infection
 Area  HBsAg  anti-HBs  neonatal  childhood
 Northern, Western, and Central Europe,North America,Australia  0.2-0.5  4-6  rare  infrequent
 Eastern Europe, theMediterranean,Russia and theRussian Federation,Southwest Asia, Central and South America  2-7  20-55  frequent  frequent
 Parts of China, Southeast Asia, tropical Africa  8-20  70-95  very frequent  very frequent

Source: http://www.who.int/csr/disease/hepatitis/whocdscsrlyo20022/en/index3.html


HEPATITIS

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